Diffuse alopecia without pattern (DUPA) is a type of androgenetic alopecia without a defined hair loss pattern. This type of alopecia manifests hair loss in all areas of the scalp, both in the upper area, as well as in the back and sides, so it lacks a stable and permanent donor area.
In the process of hair loss, the hairline is maintained, but there is a decrease in the overall hair density throughout the head.
DUPA is believed to be a genetic process. It can occur at any age and tends to occur more in women than in men; women are much more likely to suffer from DUPA than men. In men it affects to a lesser extent than DPA but it does so in a fairly accelerated manner.
The main symptom is the rapid and continuous loss of hair from all areas of the head.
Correct diagnosis of DUPA diffuse alopecia is of vital importance. Patients who suffer from it and are not pharmacologically stable should not undergo a hair transplant since their donor area is not stable and presents hair loss and, in the event of a hair transplant, would again present hair loss since these hairs are also affected by DUPA.
Dermatoscopic examination is useful to diagnose DUPA diffuse alopecia.
DUPA can be controlled by taking medications such as Finasteride, Dutasteride and Minoxidil.
Treatment with Finasteride and Dutasteride prevents 5 alpha-reductase from metabolizing testosterone into DHT and Minoxidil thickens the hair and lengthens the anagen phase of the follicle.